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Examples include azole antifungals such as itraconazole, ketoconazole , cobicistat, macrolide antibiotics such as clarithromycin, erythromycin , HIV protease inhibitors such as indinavir, ritonavir , hepatitis C virus protease inhibitors such as boceprevir, telaprevir , nefazodone, ribociclib, rifampin, among others. Do not take this medication with any other product that contains avanafil or other similar medications used to treat erectile dysfunction-ED or pulmonary hypertension such as sildenafil, tadalafil, vardenafil. Rarely, sudden decreased vision, including permanent blindness, in one or both eyes NAION may occur. Your doctor may start treatment with a lower dose of avanafil to minimize your risk of low blood pressure. Do not drive, use machinery, or do anything that needs alertness or clear vision until you can do it safely. Alcohol or marijuana cannabis can make you more dizzy. Tell you