Stendra Mechanism Of Action

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Stendra Mechanism Of Action

The recommended initial dose of Stendra is 100 mg taken approximately 30 minutes before sexual activity with or without food. The FDA approval of Stendra was based on the results of 3 randomized, double-blind, placebo-controlled, parallel group trials. headache flushing nasal congestion nasopharyngitis back pain. NO then activates the enzyme guanylate cyclase, which results in increased levels of cGMP, producing smooth muscle relaxation in the corpus cavernosum and allowing inflow of blood. The physiologic mechanism of erection of the penis involves release of nitric oxide NO in the corpus cavernosum during sexual stimulation. The trials enrolled subjects who self administered Stendra 50 mg, 100 mg, or 200 mg 30 minutes prior to initiating sexual activity. A subset of patients from 2 of these trials were enrolled into an open-label extension trial to evaluate Stendra in ED patients